The surface carbohydrates of the Echinococcus granulosus larva interact selectively with the rodent Kupffer cell receptor

Tsui Ling Hsu, Gerardo Lin, Akihiko Koizumi, Klaus Brehm, Noriyasu Hada, Po Kai Chuang, Chi Huey Wong, Shie Liang Hsieh, Alvaro Díaz

研究成果: Article査読

21 被引用数 (Scopus)

抄録

The larvae of the cestodes belonging to the genus Echinococcus dwell primarily in mammalian liver. They are protected by the laminated layer (LL), an acellular mucin-based structure. The glycans decorating these mucins constitute the overwhelming majority of molecules exposed by these larvae to their hosts. However, their decoding by host innate immunity has not been studied. Out of 36 mammalian innate receptors with carbohydrate-binding domains, expressed as Fc fusions, only the mouse Kupffer cell receptor (KCR; CLEC4F) bound significantly to the Echinococcus granulosus LL mucins. The receptor also bound the Echinococcus multilocularis LL. Out of several synthetic glycans representing Echinococcus LL structures, the KCR bound strongly in particular to those ending in Galα1-4Galβ1-3 or Galα1-4Galβ1-4GlcNAc, both characteristic LL carbohydrate motifs. LL carbohydrates may be optimized to interact with the KCR, expressed only in liver macrophages, cells known to contribute to the tolerogenic antigen presentation that is characteristic of this organ.

本文言語English
ページ(範囲)55-59
ページ数5
ジャーナルMolecular and Biochemical Parasitology
192
1-2
DOI
出版ステータスPublished - 2013 11

ASJC Scopus subject areas

  • 寄生虫科
  • 分子生物学

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