The systemic antiangiogenic effect of intravitreal aflibercept injection in a mouse model of retinopathy of prematurity

Yusuke Ichiyama, Shumpei Obata, Yoshitsugu Saishin, Osamu Sawada, Masashi Kakinoki, Tomoko Sawada, Yoshiaki Kubota, Masahito Ohji

研究成果: Article査読

2 被引用数 (Scopus)

抄録

Retinopathy of prematurity (ROP) is a leading cause of childhood blindness and intravitreal anti-vascular endothelial growth factor (VEGF) injection is becoming a first-line choice for treatment of ROP. However, there is a major concern that intravitreally injected anti-VEGF agents could escape from the eye into the systemic circulation and impair systemic development. Moreover, escaped anti-VEGF agents could have an effect on the retina of the fellow eye. In this study, we investigated the hematogenous effect of a single intravitreal anti-VEGF injection in a mouse model of ROP. Here, we showed that single intravitreal aflibercept injection to one eye can affect body weight gain, the fellow eye, and renal vessels, although no apparent effect was observed in brain vessels. Furthermore, this hematogenous effect was dose-dependent. Our results provide very important insights into the clinical use of anti-VEGF agents for ROP treatment.

本文言語English
論文番号e21390
ジャーナルFASEB Journal
35
3
DOI
出版ステータスPublished - 2021 3

ASJC Scopus subject areas

  • バイオテクノロジー
  • 生化学
  • 分子生物学
  • 遺伝学

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