The unfolded protein response in skeletal development and homeostasis

Keisuke Horiuchi, Takahide Tohmonda, Hideo Morioka

研究成果: Review article査読

31 被引用数 (Scopus)

抄録

Osteoblasts and chondrocytes produce a large number of extracellular matrix proteins to generate and maintain the skeletal system. To cope with their functions as secretory cells, these cells must acquire a considerable capacity for protein synthesis and also the machinery for the quality-control and transport of newly synthesized secreted proteins. The unfolded protein response (UPR) plays a crucial role during the differentiation of these cells to achieve this goal. Unexpectedly, however, studies in the past several years have revealed that the UPR has more extensive functions in skeletal development than was initially assumed, and the UPR critically orchestrates many facets of skeletal development and homeostasis. This review focuses on recent findings on the functions of the UPR in the differentiation of osteoblasts, chondrocytes, and osteoclasts. These findings may have a substantial impact on our understanding of bone metabolism and also on establishing treatments for congenital and acquired skeletal disorders.

本文言語English
ページ(範囲)2851-2869
ページ数19
ジャーナルCellular and Molecular Life Sciences
73
15
DOI
出版ステータスPublished - 2016 8月 1

ASJC Scopus subject areas

  • 分子医療
  • 分子生物学
  • 薬理学
  • 細胞および分子神経科学
  • 細胞生物学

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