The validity of the sentinel node concept in gastrointestinal cancers

Y. Kitagawa, H. Fujii, M. Mukai, N. Ando, T. Kubota, T. Ikeda, M. Ohgami, M. Watanabe, Y. Otani, S. Ozawa, H. Hasegawa, T. Furukawa, T. Nakahara, A. Kubo, K. Kumai, M. Kitajima

研究成果: Article査読

15 被引用数 (Scopus)

抄録

Although the sentinel node concept has been validated and clinically applied to breast cancer and malignant melanoma, its clinical significance in other solid tumors has not been thoroughly investigated. With regard to gastrointestinal (GI) cancers in particular, our surgeons have been cautious because of the high frequency of skip metastasis and the complicated lymphatic system in the GI tract. We would like to emphasize that so-called skip metastasis has been defined according to anatomic classification of regional lymph nodes and that the lymphatic drainage route must be patient or lesion specific. To test the validity and feasibility of this concept in GI cancers, we have established a radio-guided intraoperative sentinel node navigation system using preoperative endoscopic submucosal injection of radioactive tracer followed by intra-operative gamma-probing. In 131 patients with GI cancers (esophagus: 22, stomach: 71, colorectum: 38), the detection rate of sentinel nades was 91% and overall diagnostic accuracy of lymph node metastasis by sentinel node status was 97%. Initial results suggest further investigation of this procedure as an accurate staging and a minimally invasive approach to early GI cancers.

本文言語English
ページ(範囲)315-319
ページ数5
ジャーナルNippon Geka Gakkai zasshi
101
3
出版ステータスPublished - 2000 3

ASJC Scopus subject areas

  • Medicine(all)

フィンガープリント 「The validity of the sentinel node concept in gastrointestinal cancers」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル