Therapeutic activity of 1-β-D-arabinofuranosylcytosine conjugates of lipids in WEHI-3B leukemia in mice

W. E. Berdel, S. Okamoto, S. Danhauser-Riedl, C. I. Hong, E. F. Winton, C. R. West, J. Rastetter, W. R. Vogler

研究成果: Article査読

17 被引用数 (Scopus)

抄録

Two new conjugates of 1-β-arabinofuranosylcytosine (ara-C) and lipids were tested for therapeutic activity in myelomonocytic WEHI-3B leukemia in mice. Both conjugates were superior to equimolar mixtures of their respective parent compounds and to ara-C alone. IP treatment was found effective after either IP or IV transplantation of the leukemia. The thioether-linked lipid conjugate ara-CDP-D,L-PTBA showed considerably higher efficacy than the ester-linked lipid conjugate ara-CDP-L-dipalmitin. The optimal therapeutic regimen of ara-CDP-D,L-PTBA consisted of 60 mg/kg given IP qd 1-5 after transplantation of the WEHI-3B leukemia.

本文言語English
ページ(範囲)364-367
ページ数4
ジャーナルExperimental Hematology
17
4
出版ステータスPublished - 1989 1 1
外部発表はい

ASJC Scopus subject areas

  • Molecular Biology
  • Hematology
  • Genetics
  • Cell Biology
  • Cancer Research

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