抄録
Inflammatory bowel disease is thought to result from inappropriate activation of mucosal immune responses. Intestinal epithelial cells produce interleukin (IL)-7 that serves as a regulatory factor for IL-7 receptor (IL-7R)(+) mucosal lymphocytes. The pivotal role of mucosal IL-7/IL-7R dependent signals in the activation of mucosal immune responses that lead to the development of chronic intestinal inflammation are demonstrated. Therapeutic approaches targeting IL-7/IL-7R signal pathway may be feasible in the treatment of inflammatory bowel disease.
本文言語 | English |
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ページ(範囲) | 119-123 |
ページ数 | 5 |
ジャーナル | Current drug targets. Inflammation and allergy |
巻 | 2 |
号 | 2 |
DOI | |
出版ステータス | Published - 2003 6 |
外部発表 | はい |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Pharmacology