Therapeutic approaches to chronic intestinal inflammation by specific targeting of mucosal IL-7/IL-7R signal pathway.

Mamoru Watanabe; Motomi Yamazaki; Ryuichi Okamoto; Shinya Ohoka; Akihiro Araki; Tetsuya Nakamura; Takanori Kanai

doi:10.2174/1568010033484269

Therapeutic approaches to chronic intestinal inflammation by specific targeting of mucosal IL-7/IL-7R signal pathway.

Mamoru Watanabe, Motomi Yamazaki, Ryuichi Okamoto, Shinya Ohoka, Akihiro Araki, Tetsuya Nakamura, Takanori Kanai

研究成果: Review article › 査読

14 被引用数 (Scopus)

抄録

Inflammatory bowel disease is thought to result from inappropriate activation of mucosal immune responses. Intestinal epithelial cells produce interleukin (IL)-7 that serves as a regulatory factor for IL-7 receptor (IL-7R)(+) mucosal lymphocytes. The pivotal role of mucosal IL-7/IL-7R dependent signals in the activation of mucosal immune responses that lead to the development of chronic intestinal inflammation are demonstrated. Therapeutic approaches targeting IL-7/IL-7R signal pathway may be feasible in the treatment of inflammatory bowel disease.

本文言語	English
ページ（範囲）	119-123
ページ数	5
ジャーナル	Current drug targets. Inflammation and allergy
巻	2
号	2
DOI	https://doi.org/10.2174/1568010033484269
出版ステータス	Published - 2003 6
外部発表	はい

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Pharmacology

文献へのアクセス

10.2174/1568010033484269

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引用スタイル

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AU - Araki, Akihiro

AU - Nakamura, Tetsuya

AU - Kanai, Takanori

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