Therapeutic implications of cortical spreading depression models in migraine

Tsubasa Takizawa, Cenk Ayata, Shih Pin Chen

研究成果: Chapter

6 被引用数 (Scopus)

抄録

Migraine is among the most common and disabling neurological diseases in the world. Cortical spreading depression (CSD) is a wave of near-complete depolarization of neurons and glial cells that slowly propagates along the cortex creating the perception of aura. Evidence suggests that CSD can trigger migraine headache. Experimental models of CSD have been considered highly translational as they recapitulate migraine-related phenomena and have been validated for screening migraine therapeutics. Here we outline the essential components of validated experimental models of CSD and provide a comprehensive review of potential modulators and targets against CSD. We further focus on novel interventions that have been recently shown to suppress CSD susceptibility that may lead to therapeutic targets in migraine.

本文言語English
ホスト出版物のタイトルUpdate on Emerging Treatments for Migraine
編集者Shuu-Jiun Wang, Shuu-Jiun Wang, Chi Ieong Lau, Chi Ieong Lau, Chi Ieong Lau, Chi Ieong Lau, Chi Ieong Lau
出版社Elsevier B.V.
ページ29-67
ページ数39
ISBN(印刷版)9780128211083
DOI
出版ステータスPublished - 2020

出版物シリーズ

名前Progress in Brain Research
255
ISSN(印刷版)0079-6123
ISSN(電子版)1875-7855

ASJC Scopus subject areas

  • 神経科学(全般)

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