Therapeutic monoclonal antibodies

Taketo Yamada

研究成果: Review article査読

35 被引用数 (Scopus)

抄録

Over a hundred years has passed since the discovery of the "magic bullet" serum therapy by Kitasato and Behring, the first ever therapeutic use of antibodies. More than 80 years later, the investigation of immunoglobulin structure and function and the development of cell and molecular biology introduced the production of monoclonal antibodies (MoAbs). In the 35 years since the first process for creating MoAbs was introduced, they have remained the centerpiece of the growing biotechnology and pharmaceutical industry. Herein, I review the history, development, and clinical settings of therapeutic MoAbs that have had a significant impact on life-saving medicine.

本文言語English
ページ(範囲)37-46
ページ数10
ジャーナルKeio Journal of Medicine
60
2
DOI
出版ステータスPublished - 2011 6

ASJC Scopus subject areas

  • 医学(全般)

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