Thermally driven asymmetric domino reaction catalyzed by a thermostable esterase and its variants

Reina Wada, Takashi Kumon, Robert Kourist, Hiromichi Ohta, Daisuke Uemura, Shosuke Yoshida, Kenji Miyamoto

研究成果: Article査読

7 被引用数 (Scopus)

抄録

We have developed a thermally driven domino reaction for the synthesis of (S)-a-arylpropionates (profens) using a thermostable esterase from Sulfolobus tokodaii strain 7. Stereoselectivity was improved considerably by engineering of the active site. Stereoselective decarboxylation at the active site of an esterase is a new reaction for the synthesis of optically active carboxylic acids. Crown Copyright.

本文言語English
ページ(範囲)1921-1923
ページ数3
ジャーナルTetrahedron Letters
54
15
DOI
出版ステータスPublished - 2013 4月 10

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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