Thermoresponsive interfaces grafted with high-density thermoresponsive polymers; Regulated cultured cell adhesion and detachment

Aya Mizutani; Akihiko Kikuchi; Jun Kobayashi; Yoshikatsu Akiyama; Hideko Kanazawa; Teruo Okano

Thermoresponsive interfaces grafted with high-density thermoresponsive polymers; Regulated cultured cell adhesion and detachment

Aya Mizutani, Akihiko Kikuchi, Jun Kobayashi, Yoshikatsu Akiyama, Hideko Kanazawa, Teruo Okano

薬科学科

研究成果: Paper › 査読

抄録

In the present research, thermoresponsive interfaces grafted with high-density poly(N-isopropylacrylamide) (PIPAAm) are prepared by surface-initiated atom transfer radical polymerization (ATRP) on poly(p-chloromethylstyrene)-cast polystyrene surfaces. Surface characterization revealed that thermoresponsive polymers were covalently grafted onto the polystyrene surfaces. Moreover, we investigated influence of thermoresponsive surface characteristics on adhesion/detachment behavior of cultured cells. Results suggest that control of the amount of grafted PIPAAm, and also the differences in its PIPAAm constructed structure influence cell adhesion/detachment control.

本文言語	English
ページ	5399-5400
ページ数	2
出版ステータス	Published - 2006 12月 1
イベント	55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan 継続期間: 2006 9月 20 → 2006 9月 22

Other

Other	55th Society of Polymer Science Japan Symposium on Macromolecules
国/地域	Japan
City	Toyama
Period	06/9/20 → 06/9/22

ASJC Scopus subject areas

工学（全般）

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「Thermoresponsive interfaces grafted with high-density thermoresponsive polymers; Regulated cultured cell adhesion and detachment」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル

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title = "Thermoresponsive interfaces grafted with high-density thermoresponsive polymers; Regulated cultured cell adhesion and detachment",

abstract = "In the present research, thermoresponsive interfaces grafted with high-density poly(N-isopropylacrylamide) (PIPAAm) are prepared by surface-initiated atom transfer radical polymerization (ATRP) on poly(p-chloromethylstyrene)-cast polystyrene surfaces. Surface characterization revealed that thermoresponsive polymers were covalently grafted onto the polystyrene surfaces. Moreover, we investigated influence of thermoresponsive surface characteristics on adhesion/detachment behavior of cultured cells. Results suggest that control of the amount of grafted PIPAAm, and also the differences in its PIPAAm constructed structure influence cell adhesion/detachment control.",

keywords = "Cell culture, High-density polymer grafted surfaces, Poly(N-isopropylacrylamide), Surface-initiated atom transfer radical polymerization, Thermoresponsive polymer",

author = "Aya Mizutani and Akihiko Kikuchi and Jun Kobayashi and Yoshikatsu Akiyama and Hideko Kanazawa and Teruo Okano",

year = "2006",

month = dec,

day = "1",

language = "English",

pages = "5399--5400",

note = "55th Society of Polymer Science Japan Symposium on Macromolecules ; Conference date: 20-09-2006 Through 22-09-2006",

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TY - CONF

T1 - Thermoresponsive interfaces grafted with high-density thermoresponsive polymers; Regulated cultured cell adhesion and detachment

AU - Mizutani, Aya

AU - Kikuchi, Akihiko

AU - Kobayashi, Jun

AU - Akiyama, Yoshikatsu

AU - Kanazawa, Hideko

AU - Okano, Teruo

PY - 2006/12/1

Y1 - 2006/12/1

N2 - In the present research, thermoresponsive interfaces grafted with high-density poly(N-isopropylacrylamide) (PIPAAm) are prepared by surface-initiated atom transfer radical polymerization (ATRP) on poly(p-chloromethylstyrene)-cast polystyrene surfaces. Surface characterization revealed that thermoresponsive polymers were covalently grafted onto the polystyrene surfaces. Moreover, we investigated influence of thermoresponsive surface characteristics on adhesion/detachment behavior of cultured cells. Results suggest that control of the amount of grafted PIPAAm, and also the differences in its PIPAAm constructed structure influence cell adhesion/detachment control.

AB - In the present research, thermoresponsive interfaces grafted with high-density poly(N-isopropylacrylamide) (PIPAAm) are prepared by surface-initiated atom transfer radical polymerization (ATRP) on poly(p-chloromethylstyrene)-cast polystyrene surfaces. Surface characterization revealed that thermoresponsive polymers were covalently grafted onto the polystyrene surfaces. Moreover, we investigated influence of thermoresponsive surface characteristics on adhesion/detachment behavior of cultured cells. Results suggest that control of the amount of grafted PIPAAm, and also the differences in its PIPAAm constructed structure influence cell adhesion/detachment control.

KW - Cell culture

KW - High-density polymer grafted surfaces

KW - Poly(N-isopropylacrylamide)

KW - Surface-initiated atom transfer radical polymerization

KW - Thermoresponsive polymer

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T2 - 55th Society of Polymer Science Japan Symposium on Macromolecules

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