Thread-based analytical device for antibody detection in whole blood by using bioluminescent sensor proteins

Kosuke Tomimuro, Keisuke Tenda, Yuki Hiruta, Maarten Merkx, Daniel Citterio

研究成果: Conference contribution

1 被引用数 (Scopus)

抄録

Bioluminescent protein integrating microfluidic thread-based analytical devices (µTADs) for point-of-care testing (POCT) of antibodies in whole blood have been developed. Devices consist of a blood separation membrane and a plastic film layer with sewn-in cotton thread, in which proteins and luciferin for signal generation are pre-deposited. Colorimetry-based response curves for three model antibodies spiked into porcine whole blood have been obtained. Stable signals from 6-18 min after sample application and no cross-talk when assaying multiple different antibodies are observed. The µTADs offer quantitative simultaneous detection of multiple antibodies in a small volume of whole blood (8 µL).

本文言語English
ホスト出版物のタイトル22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
出版社Chemical and Biological Microsystems Society
ページ1018-1021
ページ数4
ISBN(電子版)9781510897571
出版ステータスPublished - 2018
イベント22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 - Kaohsiung, Taiwan, Province of China
継続期間: 2018 11 112018 11 15

出版物シリーズ

名前22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
2

Conference

Conference22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
CountryTaiwan, Province of China
CityKaohsiung
Period18/11/1118/11/15

ASJC Scopus subject areas

  • Chemistry(all)
  • Bioengineering
  • Chemical Engineering (miscellaneous)
  • Control and Systems Engineering

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