Three-dimensional cortex model including vascular structure for estimation of path length for optical imaging

Takahiro Kikuchi, Hiroyuki Takuwa, Kazuto Masamoto, Hiroshi Ito, Eiji Okada

    研究成果: Conference contribution

    抄録

    Optical imaging of hemoglobin concentration changes in the exposed cortex has been used to investigate the functional brain activation. The concentration changes in oxygenated and deoxygenated hemoglobin can be independently obtained from the dual-or multi-wavelength measurements of the change in reflectance of the exposed cortex and wavelength-dependent optical path length in the cortical tissues. In the previous studies, the partial optical path length were generally estimated by homogeneous and layered models. In reality, the concentration changes in the hemoglobin only occurs in the blood vessels. In this study, the partial optical path lengths in the blood vessels were estimated by the heterogeneous model including the blood vessel structure based upon the image acquired by two-photon microscopy. Light propagation in the exposed-cortex model is simulated to estimate the wavelength dependence of the partial optical path length in the blood vessels. The wavelength dependence of the partial optical path length for the heterogeneous model was different from that for the homogeneous model. In the wavelength range from 500 to 580 nm, the partial optical path length in the blood vessels was mainly affected by the structure of the blood vessels in the region shallower than 50 μm.

    本文言語English
    ホスト出版物のタイトルDiffuse Optical Imaging IV
    DOI
    出版ステータスPublished - 2013 8月 12
    イベントDiffuse Optical Imaging IV - Munich, Germany
    継続期間: 2013 5月 122013 5月 14

    出版物シリーズ

    名前Progress in Biomedical Optics and Imaging - Proceedings of SPIE
    8799
    ISSN(印刷版)1605-7422

    Other

    OtherDiffuse Optical Imaging IV
    国/地域Germany
    CityMunich
    Period13/5/1213/5/14

    ASJC Scopus subject areas

    • 電子材料、光学材料、および磁性材料
    • 生体材料
    • 原子分子物理学および光学
    • 放射線学、核医学およびイメージング

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