Three types of striational antibodies in myasthenia gravis

Shigeaki Suzuki, Kimiaki Utsugisawa, Yuriko Nagane, Norihiro Suzuki

研究成果: Review article査読

66 被引用数 (Scopus)

抄録

Myasthenia gravis (MG) is caused by antibodies that react mainly with the acetylcholine receptor on the postsynaptic site of the neuromuscular junction. A wide range of clinical presentations and associated features allow MG to be classified into subtypes based on autoantibody status. Striational antibodies, which react with epitopes on the muscle proteins titin, ryanodine receptor (RyR), and Kv1.4, are frequently found in MG patients with late-onset and thymoma. Antititin and anti-RyR antibodies are determined by enzyme-linked immunosorbent assay or immunoblot. More recently, a method for the detection of anti-Kv1.4 autoantibodies has become available, involving 12-15% of all MG patients. The presence of striational antibodies is associated with more severe disease in all MG subgroups. Anti-Kv1.4 antibody is a useful marker for the potential development of lethal autoimmune myocarditis and response to calcineurin inhibitors. Detection of striational antibodies provides more specific and useful clinical information in MG patients.

本文言語English
論文番号740583
ジャーナルAutoimmune Diseases
1
1
DOI
出版ステータスPublished - 2011

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学
  • 免疫学および微生物学(その他)

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