Three tyrosine residues in the erythropoietin receptor are essential for Janus kinase 2 V617F mutant-induced tumorigenesis

Medicine & Life Sciences

• Erythropoietin Receptors 98%
• Janus Kinase 2 98%
• Tyrosine 64%
• Carcinogenesis 53%
• Phosphorylation 29%
• Erythropoietin 22%
• STAT5 Transcription Factor 10%
• Cell Proliferation 9%
• Cytokines 8%
• Phenylalanine 7%
• Point Mutation 6%
• Protein-Tyrosine Kinases 6%
• Blood Cells 5%
• Neoplasms 4%
• Mutation 3%
• Therapeutics 1%

Chemical Compounds

• Erythropoietin 100%
• Tyrosine Residue 80%
• Oncogenic 41%
• Mutation 9%
• Phenylalanine 5%
• Tyrosine 5%