TY - JOUR
T1 - Thyroid Hormone Plays an Important Role in Cardiac Function
T2 - From Bench to Bedside
AU - Yamakawa, Hiroyuki
AU - Kato, Tomoko S.
AU - Noh, Jaeduk Yoshimura
AU - Yuasa, Shinsuke
AU - Kawamura, Akio
AU - Fukuda, Keiichi
AU - Aizawa, Yoshiyasu
N1 - Funding Information:
This work was supported by a Grant-in-Aid for Scientific Research (C) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT KAKENHI) [Grant Nos. 17K09524 (YA) and 18K08047 (HY)], the Fukuda Foundation for Medical Technology, the Daiwa Securities Health Foundation, and the Miyata Cardiac Research Promotion Foundation.
Publisher Copyright:
© Copyright © 2021 Yamakawa, Kato, Noh, Yuasa, Kawamura, Fukuda and Aizawa.
PY - 2021/10/18
Y1 - 2021/10/18
N2 - Thyroid hormones (THs) are synthesized in the thyroid gland, and they circulate in the blood to regulate cells, tissues, and organs in the body. In particular, they exert several effects on the cardiovascular system. It is well known that THs raise the heart rate and cardiac contractility, improve the systolic and diastolic function of the heart, and decrease systemic vascular resistance. In the past 30 years, some researchers have studied the molecular pathways that mediate the role of TH in the cardiovascular system, to better understand its mechanisms of action. Two types of mechanisms, which are genomic and non-genomic pathways, underlie the effects of THs on cardiomyocytes. In this review, we summarize the current knowledge of the action of THs in the cardiac function, the clinical manifestation and parameters of their hemodynamics, and treatment principles for patients with hyperthyroid- or hypothyroid-associated heart disease. We also describe the cardiovascular drugs that induce thyroid dysfunction and explain the mechanism underlying the thyroid toxicity of amiodarone, which is considered the most effective antiarrhythmic agent. Finally, we discuss the recent reports on the involvement of thyroid hormones in the regulation of myocardial regeneration and metabolism in the adult heart.
AB - Thyroid hormones (THs) are synthesized in the thyroid gland, and they circulate in the blood to regulate cells, tissues, and organs in the body. In particular, they exert several effects on the cardiovascular system. It is well known that THs raise the heart rate and cardiac contractility, improve the systolic and diastolic function of the heart, and decrease systemic vascular resistance. In the past 30 years, some researchers have studied the molecular pathways that mediate the role of TH in the cardiovascular system, to better understand its mechanisms of action. Two types of mechanisms, which are genomic and non-genomic pathways, underlie the effects of THs on cardiomyocytes. In this review, we summarize the current knowledge of the action of THs in the cardiac function, the clinical manifestation and parameters of their hemodynamics, and treatment principles for patients with hyperthyroid- or hypothyroid-associated heart disease. We also describe the cardiovascular drugs that induce thyroid dysfunction and explain the mechanism underlying the thyroid toxicity of amiodarone, which is considered the most effective antiarrhythmic agent. Finally, we discuss the recent reports on the involvement of thyroid hormones in the regulation of myocardial regeneration and metabolism in the adult heart.
KW - amiodarone
KW - cardiac regeneration
KW - cardiovascular disease
KW - genomic pathways
KW - hyperthyroidism
KW - hypothyroidism
KW - non-genomic pathways
KW - thyroid hormone
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U2 - 10.3389/fphys.2021.606931
DO - 10.3389/fphys.2021.606931
M3 - Review article
AN - SCOPUS:85118363081
VL - 12
JO - Frontiers in Physiology
JF - Frontiers in Physiology
SN - 1664-042X
M1 - 606931
ER -