Time-domain diffuse optical tomography with lp sparsity regularization for thyroid cancer imaging

Shinpei Okawa, Tetsuya Mimura, Hiroyuki Fujii, Hiroshi Kawaguchi, Yukari Tanikawa, Manabu Machida, Eiji Okada, Yoko Hoshi

研究成果: Conference contribution

抄録

Diffuse optical tomography (DOT) images the distribution of the optical properties, such as the absorption and scattering coefficients, via the image reconstruction from the light intensities measured at the surface of the biological medium. The changes in the optical properties reflect the conditions of the tissues. Therefore, DOT image can provide the information which is not obtained from the other modalities and is useful for medical diagnoses. In this study, the application of the DOT to thyroid cancer diagnosis was investigated. The ultrasound technique is usually carried out for the thyroid cancer diagnosis. It is, however, difficult to distinguish follicular carcinoma from adenoma of thyroid. The optical properties may be helpful for the diagnosis. The image reconstruction algorithm employing the regularization minimizing lp-norm (0 < p < 2) of the reconstructed image was developed. The image was reconstructed from the time-resolved measurement data. The numerical simulations of the image reconstruction were tried. The numerical simulation demonstrated that the developed algorithm was able to image the changes in the optical properties in the medium. Additionally, the image reconstruction of the numerical neck phantom was simulated. The thyroid cancer region was reconstructed successfully. It was demonstrated that the developed algorithm had the possibility to image thyroid cancer.

本文言語English
ホスト出版物のタイトルEuropean Conference on Biomedical Optics, ECBO_2019
出版社OSA - The Optical Society
ISBN(電子版)9781557528209
DOI
出版ステータスPublished - 2019
イベントEuropean Conference on Biomedical Optics, ECBO_2019 - Munich, Netherlands
継続期間: 2019 6月 232019 6月 25

出版物シリーズ

名前Optics InfoBase Conference Papers
Part F142-ECBO 2019

Conference

ConferenceEuropean Conference on Biomedical Optics, ECBO_2019
国/地域Netherlands
CityMunich
Period19/6/2319/6/25

ASJC Scopus subject areas

  • 電子材料、光学材料、および磁性材料
  • 材料力学

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