Time evolution of microenvironment around cells regulated by the secretion activity and culture density of the cells

Mai Yamagishi, Yutaka Hori, Sotaro Uemura, Osamu Ohara, Yoshitaka Shirasaki

研究成果: Conference contribution

1 被引用数 (Scopus)

抄録

Cells are the minimum unit of function for a living body. Cells are in a dynamic equilibrium state with mutually interacting with the microenvironment surrounding the cells. We focused on whether cellular responses also could be regulated in the interaction of cells with the other cells and/or the microenvironment of them. Here, we try to uncover the mechanism for the macrophages to acquire a stable response at the high cell density through simulations of the way for cell-cell communication via IFN-β. As a result, the extracellular concentration of IFN-β increased rapidly, and uniformly reached the effective concentration in any place in high-density culture condition. On the other hand, the local concentration of IFN-β in the low-density culture condition could rise transiently but easily decreased by diffusion, indicating that it was hard to reach the effective concentration in the most area. The cell density-dependent differences in IFN-β field formation were also shown to have a decisive effect on the stability of cellular responses from the population of cells. Collectively, we successfully demonstrated that the cells themselves dynamically form the surrounding microenvironment to regulate their own activity.

本文言語English
ホスト出版物のタイトルMHS 2017 - 28th 2017 International Symposium on Micro-NanoMechatronics and Human Science
出版社Institute of Electrical and Electronics Engineers Inc.
ページ1-5
ページ数5
ISBN(電子版)9781538633144
DOI
出版ステータスPublished - 2018 2月 28
イベント28th International Symposium on Micro-NanoMechatronics and Human Science, MHS 2017 - Nagoya, Japan
継続期間: 2017 12月 32017 12月 6

出版物シリーズ

名前MHS 2017 - 28th 2017 International Symposium on Micro-NanoMechatronics and Human Science
2018-January

Other

Other28th International Symposium on Micro-NanoMechatronics and Human Science, MHS 2017
国/地域Japan
CityNagoya
Period17/12/317/12/6

ASJC Scopus subject areas

  • バイオテクノロジー
  • 生体医工学
  • 電子工学および電気工学
  • 機械工学

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