Tissue adaptation of regulatory and intraepithelial CD4+ T cells controls gut inflammation

Tomohisa Sujino, Mariya London, David P.Hoytema Van Konijnenburg, Tomiko Rendon, Thorsten Buch, Hernandez M. Silva, Juan J. Lafaille, Bernardo S. Reis, Daniel Mucida

研究成果: Article

72 引用 (Scopus)

抜粋

Foxp3+ regulatory T cells in peripheral tissues (pTregs) are instrumental in limiting inflammatory responses to nonself antigens. Within the intestine, pTregs are located primarily in the lamina propria, whereas intraepithelial CD4+ T cells (CD4IELs), which also exhibit anti-inflammatory properties and depend on similar environmental cues, reside in the epithelium. Using intravital microscopy, we show distinct cell dynamics of intestinal Tregs and CD4IELs. Upon migration to the epithelium,Tregs lose Foxp3 and convert to CD4IELs in a microbiota-dependent manner, an effect attributed to the loss of the transcription factor ThPOK. Finally, we demonstrate that pTregs and CD4IELs perform complementary roles in the regulation of intestinal inflammation. These results reveal intratissue specialization of anti-inflammatory T cells shaped by discrete niches of the intestine.

元の言語English
ページ(範囲)1581-1586
ページ数6
ジャーナルScience
352
発行部数6293
DOI
出版物ステータスPublished - 2016 6 24
外部発表Yes

ASJC Scopus subject areas

  • General

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    Sujino, T., London, M., Van Konijnenburg, D. P. H., Rendon, T., Buch, T., Silva, H. M., Lafaille, J. J., Reis, B. S., & Mucida, D. (2016). Tissue adaptation of regulatory and intraepithelial CD4+ T cells controls gut inflammation. Science, 352(6293), 1581-1586. https://doi.org/10.1126/science.aaf3892