Tissue-Specific Distribution of DNA-Binding Nuclear Proteins

Hiro omi Tamura, Shunji Natori, Masuo Obinata

研究成果: Article査読

3 被引用数 (Scopus)

抄録

The DNA-binding capacity of nuclear proteins of mouse cells was examined by the protein-blotting method. Under conditions in which the lac repressor specifically binds to the lac operator, the DNA-binding nuclear proteins from different tissues showed a tissue-specific distribution, suggesting that the species and amounts of nuclear proteins with DNA binding activity differ in different tissues. When cloned eukaryotic genes were used for binding, eukaryotic DNA showed stronger binding than prokaryotic DNA. Competition experiments suggested that many nuclear proteins have different DNA binding properties from that of the prokaryotic repressor.

本文言語English
ページ(範囲)87-90
ページ数4
ジャーナルDifferentiation
23
1-3
DOI
出版ステータスPublished - 1982
外部発表はい

ASJC Scopus subject areas

  • 分子生物学
  • 発生生物学
  • 細胞生物学
  • 癌研究

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