TKI dasatinib monotherapy for a patient with Ph-like ALL bearing ATF7IP/PDGFRB translocation

Kenichiro Kobayashi; Naoyuki Miyagawa; Kazumasa Mitsui; Masaki Matsuoka; Yasuko Kojima; Hiroyuki Takahashi; Kaori Ootsubo; Junichi Nagai; Hitomi Ueno; Takeshi Ishibashi; Sara Sultana; Yoko Okada; Shingo Akimoto; Hajime Okita; Kimikazu Matsumoto; Hiroaki Goto; Nobutaka Kiyokawa; Akira Ohara

doi:10.1002/pbc.25327

TKI dasatinib monotherapy for a patient with Ph-like ALL bearing ATF7IP/PDGFRB translocation

Kenichiro Kobayashi, Naoyuki Miyagawa, Kazumasa Mitsui, Masaki Matsuoka, Yasuko Kojima, Hiroyuki Takahashi, Kaori Ootsubo, Junichi Nagai, Hitomi Ueno, Takeshi Ishibashi, Sara Sultana, Yoko Okada, Shingo Akimoto, Hajime Okita, Kimikazu Matsumoto, Hiroaki Goto, Nobutaka Kiyokawa, Akira Ohara

研究成果: Article › 査読

50 被引用数 (Scopus)

抄録

We report a 10-year-old male with relapsing Ph-like acute lymphoblastic leukemia (ALL) bearing ATF7IP/PDGFRB translocation. He was refractory to conventional therapy, and was finally treated with single-agent second-generation TKI dasatinib. The therapeutic response was prompt, with the disappearance of minimum residual disease (MRD) based on genomic PCR analysis within 3 months, and he has maintained complete molecular remission for 12 months. This case report describes an early-phase response to TKI monotherapy on Ph-like ALL, and technical tips for MRD monitoring on long-term follow-up.

本文言語	English
ページ（範囲）	1058-1060
ページ数	3
ジャーナル	Pediatric Blood and Cancer
巻	62
号	6
DOI	https://doi.org/10.1002/pbc.25327
出版ステータス	Published - 2015 6月 1
外部発表	はい

ASJC Scopus subject areas

小児科学、周産期医学および子どもの健康
血液学
腫瘍学

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10.1002/pbc.25327

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Kobayashi, K., Miyagawa, N., Mitsui, K., Matsuoka, M., Kojima, Y., Takahashi, H., Ootsubo, K., Nagai, J., Ueno, H., Ishibashi, T., Sultana, S., Okada, Y., Akimoto, S., Okita, H., Matsumoto, K., Goto, H., Kiyokawa, N., & Ohara, A. (2015). TKI dasatinib monotherapy for a patient with Ph-like ALL bearing ATF7IP/PDGFRB translocation. Pediatric Blood and Cancer, 62(6), 1058-1060. https://doi.org/10.1002/pbc.25327

TKI dasatinib monotherapy for a patient with Ph-like ALL bearing ATF7IP/PDGFRB translocation. / Kobayashi, Kenichiro; Miyagawa, Naoyuki; Mitsui, Kazumasa; Matsuoka, Masaki; Kojima, Yasuko; Takahashi, Hiroyuki; Ootsubo, Kaori; Nagai, Junichi; Ueno, Hitomi; Ishibashi, Takeshi; Sultana, Sara; Okada, Yoko; Akimoto, Shingo; Okita, Hajime; Matsumoto, Kimikazu; Goto, Hiroaki; Kiyokawa, Nobutaka; Ohara, Akira.

In: Pediatric Blood and Cancer, Vol. 62, No. 6, 01.06.2015, p. 1058-1060.

研究成果: Article › 査読

Kobayashi, K, Miyagawa, N, Mitsui, K, Matsuoka, M, Kojima, Y, Takahashi, H, Ootsubo, K, Nagai, J, Ueno, H, Ishibashi, T, Sultana, S, Okada, Y, Akimoto, S, Okita, H, Matsumoto, K, Goto, H, Kiyokawa, N & Ohara, A 2015, 'TKI dasatinib monotherapy for a patient with Ph-like ALL bearing ATF7IP/PDGFRB translocation', Pediatric Blood and Cancer, vol. 62, no. 6, pp. 1058-1060. https://doi.org/10.1002/pbc.25327

Kobayashi, Kenichiro ; Miyagawa, Naoyuki ; Mitsui, Kazumasa ; Matsuoka, Masaki ; Kojima, Yasuko ; Takahashi, Hiroyuki ; Ootsubo, Kaori ; Nagai, Junichi ; Ueno, Hitomi ; Ishibashi, Takeshi ; Sultana, Sara ; Okada, Yoko ; Akimoto, Shingo ; Okita, Hajime ; Matsumoto, Kimikazu ; Goto, Hiroaki ; Kiyokawa, Nobutaka ; Ohara, Akira. / TKI dasatinib monotherapy for a patient with Ph-like ALL bearing ATF7IP/PDGFRB translocation. In: Pediatric Blood and Cancer. 2015 ; Vol. 62, No. 6. pp. 1058-1060.

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abstract = "We report a 10-year-old male with relapsing Ph-like acute lymphoblastic leukemia (ALL) bearing ATF7IP/PDGFRB translocation. He was refractory to conventional therapy, and was finally treated with single-agent second-generation TKI dasatinib. The therapeutic response was prompt, with the disappearance of minimum residual disease (MRD) based on genomic PCR analysis within 3 months, and he has maintained complete molecular remission for 12 months. This case report describes an early-phase response to TKI monotherapy on Ph-like ALL, and technical tips for MRD monitoring on long-term follow-up.",

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TKI dasatinib monotherapy for a patient with Ph-like ALL bearing ATF7IP/PDGFRB translocation

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