TMS orientation for NIRS-functional motor mapping

Takenori Akiyama, Takayuki Ohira, Takeshi Kawase, Toshinori Kato

研究成果: Article査読

33 被引用数 (Scopus)

抄録

Functional near-infrared spectroscopic imaging (NIRS imaging) has the potential to elucidate the relationship between neuronal activity and oxygenation responses. However, its signal specificity to the functional cortex is sometimes spoiled by its rough spatial resolution. In this study we incorporated transcranial magnetic stimulation (TMS) motor mapping into an NIRS imaging study to enhance spatial specificity to the functional cortex. Distinctive biphasic responses in the cortical oxygenation status were observed in the center of the primary motor cortex during a motor task. The early response phase, occurring within 1 to 3 seconds after task initiation, represents a cortical deoxygenation which consists of a significant increase in deoxygenated hemoglobin concentration (HbR) and a nonsignificant decreasing tendency in oxygenated hemoglobin concentration (HbO2). The delayed response phase represents an excess of incoming blood flow, which appears as an increase in HbO2/total Hb (tHb) and a decrease in HbR following the early response. In the surrounding area, cortical oxygenation change showed a monophasic response consisting of an increase in HbO2/tHb and a decrease in HbR. Combining TMS mapping with NIRS imaging enabled us to specify the cortex with the strongest functional activity.

本文言語English
ページ(範囲)1-9
ページ数9
ジャーナルBrain Topography
19
1-2
DOI
出版ステータスPublished - 2006 12

ASJC Scopus subject areas

  • 解剖学
  • 放射線技術および超音波技術
  • 放射線学、核医学およびイメージング
  • 神経学
  • 臨床神経学

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