Toll-like receptors, NOD1, and NOD2 in oral epithelial cells

Y. Sugawara, A. Uehara, Y. Fujimoto, S. Kusumoto, K. Fukase, K. Shibata, S. Sugawara, T. Sasano, H. Takada

研究成果: Article査読

120 被引用数 (Scopus)

抄録

Oral epithelium might be the first barrier against oral bacteria in periodontal tissue. We hypothesized that oral epithelium is endowed with innate immune receptors for bacterial components, which play roles in host defense against bacterial infection without being accompanied by excessive inflammatory responses. We found clear expression of Toll-like receptor (TLR)4 as well as TLR2, and strong expression of NOD1 and NOD2 in normal oral epithelial tissues by immunohistochemical analysis. We also showed that primary oral epithelial cells in culture expressed these molecules using PCR, flow cytometry, and immunostaining. In inflamed oral epithelium, cell-surface localizations of TLR2 and TLR4 were more clearly observed than in healthy tissue. Upon stimulation with synthetic ligands for these receptors, the expression of β-defensin 2 was markedly up-regulated. These findings indicate that these molecules in oral epithelial cells are functional receptors that induce antibacterial responses.

本文言語English
ページ(範囲)524-529
ページ数6
ジャーナルJournal of Dental Research
85
6
DOI
出版ステータスPublished - 2006 6
外部発表はい

ASJC Scopus subject areas

  • Dentistry(all)

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