Total Syntheses of (+)-Aquatolide and Related Humulanolides

Ken ichi Takao, Hirotaka Kai, Ai Yamada, Yuuki Fukushima, Daisuke Komatsu, Akihiro Ogura, Keisuke Yoshida

研究成果: Article査読

10 被引用数 (Scopus)

抄録

The short, efficient total synthesis of (+)-aquatolide was achieved by a biomimetic transannular [2+2] photocycloaddition, and provides the first example of constructing a 5/5/4/8-ring system from asteriscunolides. Furthermore, the reaction leading to a 5/4/4/7-ring system, the originally proposed structure of aquatolide, was also developed. This strategy achieved syntheses of five more humulanolides, (−)-asteriscunolides A, C, D, and I, and (+)-tetradehydroasteriscanolide.

本文言語English
ページ(範囲)9851-9855
ページ数5
ジャーナルAngewandte Chemie - International Edition
58
29
DOI
出版ステータスPublished - 2019 7 15

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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