Total syntheses of lactonamycin and lactonamycin Z with late-stage a-ring formation and glycosylation

Satoshi Adachi, Kana Watanabe, Yusuke Iwata, Shunsuke Kameda, Yoshihito Miyaoka, Masao Onozuka, Ryo Mitsui, Yoko Saikawa, Masaya Nakata

研究成果: Article査読

35 被引用数 (Scopus)

抄録

The highly oxygenated polyketide antibiotics, lactonamycin and lactonamycin Z were synthesized. The BCDEF ring system was constructed by a cycloaddition and a palladium-catalyzed cyclization and a Bischler-Napieralski-type cyclization was used for the formation of the A ring. The glycosylation of the aglycon with the appropriate sugar gave lactonamycin and lactonamycin Z.

本文言語English
ページ(範囲)2087-2091
ページ数5
ジャーナルAngewandte Chemie - International Edition
52
7
DOI
出版ステータスPublished - 2013 2 11

ASJC Scopus subject areas

  • 触媒
  • 化学 (全般)

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