Total syntheses of natural tubelactomicins B, D, and E: Establishment of their stereochemistries

Kiyoto Sawamura, Keigo Yoshida, Akari Suzuki, Toru Motozaki, Ikuko Kozawa, Takashi Hayamizu, Ryosuke Munakata, Ken Ichi Takao, Kin Ichi Tadano

研究成果: Article査読

19 被引用数 (Scopus)

抄録

(Chemical Equation Presented) Total syntheses of the antimicrobial tricyclic 16-membered macrolides, (+)-tubelactomicin B, (+)-tubelactomicin D, and (+)-tubelactomicin E, have been accomplished for the first time with common synthetic approaches. These total syntheses established the relative and absolute configurations of the three tubelactomicins, for which planar structures had solely been reported. The total synthesis of (+)-tubelactomicin D included a newly developed stereoselective intramolecular Diels-Alder reaction for constructing the highly functionalized octahydronaphthalene substructures.

本文言語English
ページ(範囲)6143-6148
ページ数6
ジャーナルJournal of Organic Chemistry
72
16
DOI
出版ステータスPublished - 2007 8月 1

ASJC Scopus subject areas

  • 有機化学

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