Total synthesis and evaluation of Wnt signal inhibition of melleumin A and B, and their derivatives

Midori A. Arai, Shuwa Hanazawa, Yujiro Uchino, Xiaofan Li, Masami Ishibashi

研究成果: Article査読

7 被引用数 (Scopus)

抄録

The total synthesis of melleumin A (1), a novel cyclic depsipeptide isolated from the myxomycete Physarum melleum, and 3-epi-melleumin A (6) was achieved. Melleumin A-like compounds were also designed and synthesized; analysis of these melleumin A-like compounds showed moderate Wnt signal inhibition. Comparison of the inhibition activity of melleumin B and its three epimers, melleumin A, 3-epi-melleumin A and three melleumin A-like compounds led to further investigation of the structural conformation of the active molecules. The scaffold of melleumin is a potential target in the search for "peptide-like" Wnt signaling inhibitors.

本文言語English
ページ(範囲)5285-5293
ページ数9
ジャーナルOrganic and Biomolecular Chemistry
8
23
DOI
出版ステータスPublished - 2010 12月 7
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 物理化学および理論化学
  • 有機化学

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