Total synthesis and stereochemical determination of yoshinone A

Seiichi Shinomiya, Arihiro Iwasaki, Osamu Ohno, Kiyotake Suenaga

研究成果: Article査読

5 被引用数 (Scopus)

抄録

In 2014, the γ-pyrone-containing polyketide, yoshinone A, was isolated from the marine cyanobacterium Leptolyngbya sp. and its structure was determined. Yoshinone A inhibited differentiation of 3T3-L1 cells into adipocytes, with an EC50 value of 420 nM without any cytotoxicity, and therefore is expected to be a lead compound for obesity drugs. To establish its absolute configuration, and to provide sufficient amounts for further research, the total synthesis of yoshinone A was achieved through synthesis of its two possible diastereomers.

本文言語English
ページ(範囲)109-114
ページ数6
ジャーナルPhytochemistry
132
DOI
出版ステータスPublished - 2016 12 1

ASJC Scopus subject areas

  • 生化学
  • 分子生物学
  • 植物科学
  • 園芸学

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