Total Synthesis and Structural Revision of Clavilactone D

Ken Ichi Takao, Ryuichi Nemoto, Kento Mori, Ayumi Namba, Keisuke Yoshida, Akihiro Ogura

研究成果: Article査読

14 被引用数 (Scopus)

抄録

A structural revision of clavilactone D, a potent inhibitor of protein tyrosine kinases, was achieved by total syntheses of two newly proposed structures. The syntheses relied on ring-opening/ring-closing metathesis, which transformed a cyclobutenecarboxylate into a γ-butenolide. The syntheses confirmed that the correct structure of clavilactone D has an amino group at C-3 instead of a hydroxy group at C-2 in the originally proposed structure.

本文言語English
ページ(範囲)3828-3831
ページ数4
ジャーナルChemistry - A European Journal
23
16
DOI
出版ステータスPublished - 2017 3 17

ASJC Scopus subject areas

  • 触媒
  • 有機化学

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