Total synthesis of attenols A and B

Keisuke Araki, Kiyotake Suenaga, Tetsuya Sengoku, Daisuke Uemura

研究成果: Article査読

42 被引用数 (Scopus)

抄録

The enantioselective synthesis of attenols A and B, cyclic polyethers of marine origin, was accomplished on a semigram scale by using diastereoselective hydroboration, coupling with lithium acetylide, Lindlar reduction and acid-catalyzed acetal formation. The configuration of the remaining undetermined spiro acetal carbon was unambiguously determined to be 11S using this ample supply of attenol A. The antitumor activities of synthetic attenol A were also examined.

本文言語English
ページ(範囲)1983-1995
ページ数13
ジャーナルTetrahedron
58
10
DOI
出版ステータスPublished - 2002 3月 4
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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