Total Synthesis of Cardiolipins Containing Chiral Cyclopropane Fatty Acids

Shinsuke Inuki, Ippei Ohta, Shunichi Ishibashi, Masayuki Takamatsu, Koichi Fukase, Yukari Fujimoto

研究成果: Article

3 引用 (Scopus)

抄録

Cardiolipin (CL) is a phospholipid located in both the eukaryotic mitochondrial inner membrane and the bacterial cell membrane. Some bacterial CLs are known to contain cyclopropane moieties in their acyl chains. Although the CLs are thought to be involved in the innate immune response, there have been few attempts at chemical synthesis of the CLs, and detailed studies of their biological activities are scarce. Thus, we have developed a synthetic route to CLs containing chiral cyclopropane moieties.

元の言語English
ページ(範囲)7832-7838
ページ数7
ジャーナルJournal of Organic Chemistry
82
発行部数15
DOI
出版物ステータスPublished - 2017 8 4

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Cardiolipins
Cell membranes
Bioactivity
Phospholipids
Membranes
cyclopropane
cyclopropane fatty acids

ASJC Scopus subject areas

  • Organic Chemistry

これを引用

Total Synthesis of Cardiolipins Containing Chiral Cyclopropane Fatty Acids. / Inuki, Shinsuke; Ohta, Ippei; Ishibashi, Shunichi; Takamatsu, Masayuki; Fukase, Koichi; Fujimoto, Yukari.

:: Journal of Organic Chemistry, 巻 82, 番号 15, 04.08.2017, p. 7832-7838.

研究成果: Article

Inuki, S, Ohta, I, Ishibashi, S, Takamatsu, M, Fukase, K & Fujimoto, Y 2017, 'Total Synthesis of Cardiolipins Containing Chiral Cyclopropane Fatty Acids', Journal of Organic Chemistry, 巻. 82, 番号 15, pp. 7832-7838. https://doi.org/10.1021/acs.joc.7b00945
Inuki, Shinsuke ; Ohta, Ippei ; Ishibashi, Shunichi ; Takamatsu, Masayuki ; Fukase, Koichi ; Fujimoto, Yukari. / Total Synthesis of Cardiolipins Containing Chiral Cyclopropane Fatty Acids. :: Journal of Organic Chemistry. 2017 ; 巻 82, 番号 15. pp. 7832-7838.
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