Total synthesis of complex alkaloids by nucleophilic addition to amides

Takaaki Sato, Makoto Yoritate, Hayato Tajima, Noritaka Chida

研究成果: Article査読

57 被引用数 (Scopus)

抄録

Nucleophilic addition to amides has been recognized as a promising transformation for total synthesis of complex alkaloids. Amides can accept two different organometallic reagents through the nucleophilic addition, which enables it to serve as a stable surrogate of multi-substituted amines. However, the nucleophilic addition has been overlooked for a long time due to three main reasons: low electrophilicity of amide carbonyls, potential hydrolysis of the reaction intermediate and excess addition of an organometallic reagent. This mini review focuses on the recent progress of total synthesis of complex alkaloids based on the nucleophilic additions to N-alkoxyamides, tertiary amides and secondary amides.

本文言語English
ページ(範囲)3864-3875
ページ数12
ジャーナルOrganic and Biomolecular Chemistry
16
21
DOI
出版ステータスPublished - 2018

ASJC Scopus subject areas

  • 生化学
  • 物理化学および理論化学
  • 有機化学

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