Total synthesis of homoerythrinan alkaloids, schelhammericine and 3-epischelhammericine

Yoshisuke Tsuda, Takeshi Ohshima, Shinzo Hosoi, Satomi Kaneuchi, Fumiyuki Kiuchi, Jun Toda, Takehiro Sano

研究成果: Article

20 引用 (Scopus)

抜粋

Total syntheses of two homoerythrinan alkaloids, schelhammericine and 3-epischelhammericine, are described. Photocycloaddition of a dioxopyrrolobenzazepine to 1-methoxy-3-trimethylsilyloxybutadiene afforded, in a regio- and stereo-specific manner, the cyclobutane derivative, which was converted to a homoerythrinan derivative by utilizing a TBAF-induced 1,3-anionic rearrangement. The product was transformed into the title alkaloids in several steps.

元の言語English
ページ(範囲)500-508
ページ数9
ジャーナルChemical and Pharmaceutical Bulletin
44
発行部数3
出版物ステータスPublished - 1996 3 1
外部発表Yes

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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  • これを引用

    Tsuda, Y., Ohshima, T., Hosoi, S., Kaneuchi, S., Kiuchi, F., Toda, J., & Sano, T. (1996). Total synthesis of homoerythrinan alkaloids, schelhammericine and 3-epischelhammericine. Chemical and Pharmaceutical Bulletin, 44(3), 500-508.