Total Synthesis of Kanamienamide and Clarification of Biological Activity

研究成果: Article査読

4 被引用数 (Scopus)

抄録

The total synthesis of kanamienamide, an enamide with an enol ether and an 11-membered macrolactone of marine origin, was achieved. The synthesis features the construction of an enamide adjacent to an enol ether by Buchwald amidation and an 11-membered ring by Mitsunobu lactonization. In addition, on the basis of the biological assay of synthetic 1, we clarified that kanamienamide (1) was not an apoptosis-like cell death inducer, as reported in the isolation paper, and revealed its real biological activity as a necrosis-like cell death inducer.

本文言語English
ページ(範囲)12503-12510
ページ数8
ジャーナルJournal of Organic Chemistry
82
23
DOI
出版ステータスPublished - 2017 12月 1

ASJC Scopus subject areas

  • 有機化学

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