Total Synthesis of Miuraenamides A and D

Daisuke Ojima, Ayano Yasui, Koh Tohyama, Keita Tokuzumi, Eisuke Toriihara, Kayoko Ito, Arihiro Iwasaki, Tomohiko Tomura, Makoto Ojika, Kiyotake Suenaga

研究成果: Article査読

11 被引用数 (Scopus)

抄録

Miuraenamides A and D, cyclodepsipeptides with antimicrobial and antitumor activity, were synthesized. The synthesis of an unsaturated hydroxycarboxylic acid moiety, starting from a chiral epoxide, was achieved by Suzuki-Miyaura coupling as a key step. As a result, the overall yield for miuraenamide A over the longest linear sequence is 3.2%, while the yield of the previously reported procedure is 1.9%. In addition, the cell growth-inhibitory activity and anti-Phytophthora activity of the synthesized compounds were evaluated.

本文言語English
ページ(範囲)9886-9894
ページ数9
ジャーナルJournal of Organic Chemistry
81
20
DOI
出版ステータスPublished - 2016 10月 21

ASJC Scopus subject areas

  • 有機化学

フィンガープリント

「Total Synthesis of Miuraenamides A and D」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル