Total synthesis of murrastifoline-A by way of the Pd-catalyzed double N-arylation of a carbazolamine with a 2,2′-dibromobiphenyl derivative

Takafumi Kitawaki, Yoko Hayashi, Noritaka Chida

研究成果: Article査読

34 被引用数 (Scopus)

抄録

The first total synthesis of murrastifoline-A (1), a biscarbazole alkaloid is described. The biscarbazole skeleton of 1 was effectively constructed by the Pd-catalyzed double N-arylation of carbazolamine (bottom-half segment, 3) with dibromobiphenyl derivative (top-half segment, 2) in one-step reaction. Both segments were synthesized starting from 2-amino-5-methylphenol (4).

本文言語English
ページ(範囲)1561-1567
ページ数7
ジャーナルHeterocycles
65
7
DOI
出版ステータスPublished - 2005 7月 1

ASJC Scopus subject areas

  • 分析化学
  • 薬理学
  • 有機化学

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