Total synthesis of mycestericin A

Hideyuki Sato, Kazuya Sato, Masatoshi Iida, Hiroyoshi Yamanaka, Takeshi Oishi, Noritaka Chida

研究成果: Article査読

18 被引用数 (Scopus)

抄録

The first total synthesis of mycestericin A (1) starting from tartrates is described. The Overman rearrangement of an allylic trichloroacetimidate generated a tetra-substituted carbon with nitrogen, and subsequent stereoselective transformations afforded the highly functionalized vinyl iodide. The cross-coupling of the vinyl iodide with a chiral organozinc species under Negishi conditions, followed by deprotection, completed the total synthesis of 1.

本文言語English
ページ(範囲)1943-1947
ページ数5
ジャーナルTetrahedron Letters
49
12
DOI
出版ステータスPublished - 2008 3 17

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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