Total synthesis of (±)-mycoepoxydiene, a novel fungal metabolite having an oxygen-bridged cyclooctadiene skeleton

Ken Ichi Takao, Gohshi Watanabe, Hiroyuki Yasui, Kin Ichi Tadano

研究成果: Article査読

52 被引用数 (Scopus)

抄録

The first total synthesis of (±)-mycoepoxydiene has been accomplished. A ring-closing olefin metathesis (RCM) approach was employed for the construction of the oxygen-bridged eight-membered bicyclic skeleton. The RCM product was converted to the target natural product featuring the oxidative rearrangement of a furfuryl alcohol introduced as the side chain and the stereoselective 1,2-reduction of a δ-keto-β,γ-unsaturated α-lactol intermediate.

本文言語English
ページ(範囲)2941-2943
ページ数3
ジャーナルOrganic Letters
4
17
DOI
出版ステータスPublished - 2002 8月 22

ASJC Scopus subject areas

  • 生化学
  • 物理化学および理論化学
  • 有機化学

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