In this Account, we describe our studies on the total synthesis of several natural products using intramolecular Nozaki-Hiyama-Takai-Kishi (NHTK) reactions. In each synthesis, an NHTK reaction is used to efficiently construct a medium-sized ring. These examples demonstrate the utility of the intramolecular NHTK reaction in natural product synthesis. 1 Introduction 2 Total Synthesis of (+)-Pestalotiopsin A 3 Total Synthesis of (+)-Cytosporolide A 4 Total Synthesis of (+)-Vibsanin A 5 Total Syntheses of (+)-Aquatolide and Related Humulanolides 6 Conclusion.
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