Total synthesis of natural products using sequential olefin metathesis reactions

Ken Ichi Takao, Keisuke Yoshida, Kin Ichi Tadano

研究成果: Article査読

2 被引用数 (Scopus)

抄録

Olefin metathesis is established as a remarkably valuable synthetic tool in current organic chemistry. We report here total synthesis of natural products using sequential olefin metathesis reactions. The one - pot ring - opening/cross/ring - closing metathesis (ROM/CM/RCM) reaction has been developed, allowing for the concise construction of the oxygen - bridged 1,3 - cycloocta-diene framework from an oxanorbornene derivative and 1,3-butadiene. The ROM/CM/RCM product was converted into (+)-mycoepoxydiene, (-)-1893A, and (+)-1893B. Furthermore, the ring - opening/ring - closing metathesis (ROM/RCM) of cyclobutenecarboxylate derivatives has been developed as a novel method for access to γ- butenolides. The enantioselective total synthesis of (+)-clavilactone A and (-)-clavilactone B was achieved by the use of this reaction (ROM/RCM).

本文言語English
ページ(範囲)1192-1199
ページ数8
ジャーナルYuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
73
12
出版ステータスPublished - 2015

ASJC Scopus subject areas

  • Organic Chemistry

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