抄録
The total synthesis of palytoxin carboxylic acid and palytoxin amide was achieved from the fully protected palytoxin carboxylic acid. The fully protected palytoxin carboxylic acid 1 contains eight different and 42 total protecting groups. All these protecting groups were successfully removed in five synthetic operations, i.e., (1) DDQ treatment, (2) aqueous HClO4 hydrolysis, (3) aqueous LiOH hydrolysis, (4) (n-Bu)4NF treatment, and (5) aqueous AcOH hydrolysis. The completely deprotected palytoxin carboxylic acid was isolated in approximately 35% overall yield and identified with the authentic sample. An efficient method to convert palytoxin carboxylic acid 2 into palytoxin amide 3 was developed.
本文言語 | English |
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ページ(範囲) | 7530-7533 |
ページ数 | 4 |
ジャーナル | Journal of the American Chemical Society |
巻 | 111 |
号 | 19 |
DOI | |
出版ステータス | Published - 1989 9月 |
外部発表 | はい |
ASJC Scopus subject areas
- 触媒
- 化学 (全般)
- 生化学
- コロイド化学および表面化学