The total synthesis of the antifungal antibiotic, polyoxin J 1 starting from myo-inositol is described; the two key components, 2 and 3, were prepared from a pair of optically resolved myo-inositol derivatives 4L and 4D, respectively, using a highly regioselective Baeyer-Villiger reaction, and finally coupled to complete the total synthesis.
|ジャーナル||Journal of the Chemical Society, Chemical Communications|
|出版物ステータス||Published - 1994 12 1|
ASJC Scopus subject areas
- Molecular Medicine