Total Synthesis of Skipped Diene Natural Products

Takaaki Sato, Takahiro Suto, Yoshiyuki Nagashima, Shori Mukai, Noritaka Chida

研究成果: Review article査読

抄録

Skipped dienes (1,4-dienes) are widely distributed in a variety of biologically active natural products. The synthesis of these skipped dienes is a relatively undeveloped area compared with that of conjugated dienes (1,3-dienes) due to the sp3-hybridized carbon between two olefins. Especially, development of methods to meet both high stereoselectivity and convergency is highly challenging. This review focuses on recent advances in the synthesis of skipped dienes in the total synthesis of complex natural products, which are classified into three classes; a) skipped dienes comprised of two disubstituted olefins, b) skipped dienes including trisubstituted olefin(s), and c) 3-methyl skipped dienes.

本文言語English
ページ(範囲)2486-2502
ページ数17
ジャーナルAsian Journal of Organic Chemistry
10
10
DOI
出版ステータスPublished - 2021 10

ASJC Scopus subject areas

  • 有機化学

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