Over the past three decades, a variety of highly functionalized /-lactam or spiro-heterocyclic γ-lactam natural products have been isolated. These compounds have attracted considerable attention due to their structural uniqueness as well as interesting biological activities. Thus, numerous synthetic organic chemists have established new methodologies for access to the y-lactam-type compounds. In this review, we summarize completed total syntheses of natural products containing a γ-lactam structure, such as ( - )-PI-091, (+)-epolactaene, lucilactaene, ( - )-pramanicin, ( - )-pseurotin A, ( - )-pseurotin F2, (+)-synerazol, and ( - )-azaspirene.
|ジャーナル||Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry|
|出版ステータス||Published - 2007 5|
ASJC Scopus subject areas
- Organic Chemistry