Total Synthesis of the Cytotoxic Macrocycle (+)-Hitachimycin

Amos B. Smith, Thomas A. Rano, Noritaka Chida, Gary A. Sulikowski, John L. Wood

研究成果: Article査読

48 被引用数 (Scopus)

抄録

The first total synthesis of the antitumor antibiotic (+)-hitachimycin (a.k.a. stubomycin) (1) has been achieved in 22 steps and 1.1% overall yield. The cornerstone of the synthetic strategy was a highly stereoselective three-component coupling of (-)-5-methoxycyclopentenone (4) with a zincate derived from vinyl iodide 3a and aldehyde (-)-51.

本文言語English
ページ(範囲)8008-8022
ページ数15
ジャーナルJournal of the American Chemical Society
114
21
DOI
出版ステータスPublished - 1992 10 1
外部発表はい

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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