Total synthesis of the trisaccharide of olivomycin A

Kazunobu Toshima, Yuko Nozaki, Masaya Nakata, Kuniaki Tatsuta, Mitsuhiro Kinoshita

研究成果: Article査読

9 被引用数 (Scopus)

抄録

The total synthesis of the trisaccharide of olivomycin A, which is one of the aureolic acid antitumor antibiotics, has been achieved. Our approach involves highly stereocontrolled glycosidations using 2,6-ahnydro-2-thio glycosyl donors. The 2,6-anhydro-2-thio trisaccharide 21 was constructed from 4 and 5, and then converted into the 2,6-dideoxy trisaccharide of olivomycin A 3 by hydrogenolysis and deprotection.

本文言語English
ページ(範囲)5761-5764
ページ数4
ジャーナルTetrahedron Letters
34
36
DOI
出版ステータスPublished - 1993 9 3

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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