Total synthesis of (+)-tubelactomicin A. 2. Synthesis of the upper-half segment and completion of the total synthesis

Toru Motozaki; Kiyoto Sawamura; Akari Suzuki; Keigo Yoshida; Tatsuo Ueki; Aiko Ohara; Ryosuke Munakata; Ken Ichi Takao; Kin Ichi Tadano

doi:10.1021/ol050763x

Total synthesis of (+)-tubelactomicin A. 2. Synthesis of the upper-half segment and completion of the total synthesis

Toru Motozaki, Kiyoto Sawamura, Akari Suzuki, Keigo Yoshida, Tatsuo Ueki, Aiko Ohara, Ryosuke Munakata, Ken Ichi Takao, Kin Ichi Tadano

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研究成果: Article › 査読

43 被引用数 (Scopus)

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(Chemical Equation Presented) We have completed the total synthesis of natural (+)-tubelactomicin A (1), a 16-membered macrolide antibiotic. This Letter presents a highly efficient synthesis of the upper-half segment (C14-C24) and the completion of the total synthesis featuring a high-yielding Stille coupling for the connection of the upper-half and lower-half segments and Mukaiyama macrolactonization for the construction of the entire structure of 1.

本文言語	English
ページ（範囲）	2265-2267
ページ数	3
ジャーナル	Organic Letters
巻	7
号	11
DOI	https://doi.org/10.1021/ol050763x
出版ステータス	Published - 2005 5月 26

ASJC Scopus subject areas

生化学
物理化学および理論化学
有機化学

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10.1021/ol050763x

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title = "Total synthesis of (+)-tubelactomicin A. 2. Synthesis of the upper-half segment and completion of the total synthesis",

abstract = "(Chemical Equation Presented) We have completed the total synthesis of natural (+)-tubelactomicin A (1), a 16-membered macrolide antibiotic. This Letter presents a highly efficient synthesis of the upper-half segment (C14-C24) and the completion of the total synthesis featuring a high-yielding Stille coupling for the connection of the upper-half and lower-half segments and Mukaiyama macrolactonization for the construction of the entire structure of 1.",

author = "Toru Motozaki and Kiyoto Sawamura and Akari Suzuki and Keigo Yoshida and Tatsuo Ueki and Aiko Ohara and Ryosuke Munakata and Takao, {Ken Ichi} and Tadano, {Kin Ichi}",

year = "2005",

month = may,

day = "26",

doi = "10.1021/ol050763x",

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T1 - Total synthesis of (+)-tubelactomicin A. 2. Synthesis of the upper-half segment and completion of the total synthesis

AU - Motozaki, Toru

AU - Sawamura, Kiyoto

AU - Suzuki, Akari

AU - Yoshida, Keigo

AU - Ueki, Tatsuo

AU - Ohara, Aiko

AU - Munakata, Ryosuke

AU - Takao, Ken Ichi

AU - Tadano, Kin Ichi

PY - 2005/5/26

Y1 - 2005/5/26

N2 - (Chemical Equation Presented) We have completed the total synthesis of natural (+)-tubelactomicin A (1), a 16-membered macrolide antibiotic. This Letter presents a highly efficient synthesis of the upper-half segment (C14-C24) and the completion of the total synthesis featuring a high-yielding Stille coupling for the connection of the upper-half and lower-half segments and Mukaiyama macrolactonization for the construction of the entire structure of 1.

AB - (Chemical Equation Presented) We have completed the total synthesis of natural (+)-tubelactomicin A (1), a 16-membered macrolide antibiotic. This Letter presents a highly efficient synthesis of the upper-half segment (C14-C24) and the completion of the total synthesis featuring a high-yielding Stille coupling for the connection of the upper-half and lower-half segments and Mukaiyama macrolactonization for the construction of the entire structure of 1.

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DO - 10.1021/ol050763x

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VL - 7

SP - 2265

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JO - Organic Letters

JF - Organic Letters

SN - 1523-7060

IS - 11

ER -

Total synthesis of (+)-tubelactomicin A. 2. Synthesis of the upper-half segment and completion of the total synthesis

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