Total Synthesis of Tunicamycin v

Kazuki Yamamoto, Fumika Yakushiji, Takanori Matsumaru, Satoshi Ichikawa

研究成果: Article査読

14 被引用数 (Scopus)

抄録

The total synthesis of tunicamycin V is described. This strategy is based on the initial construction of tunicaminyluracil, which is regarded to play an important role in the observed biological activities. The key to the synthesis was a Mukaiyama aldol reaction followed by a furan-oxidation to construct the undecose skeleton, a [3,3] sigmatropic rearrangement of a cyanate, and a highly selective trehalose-type glycosylation.

本文言語English
ページ(範囲)256-259
ページ数4
ジャーナルOrganic Letters
20
1
DOI
出版ステータスPublished - 2018 1 5
外部発表はい

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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