抄録
The reported structure of the natural calafianin (1) and its isomer in the epoxide region 13 were successfully synthesized through the cis- and trans-spiroisoxazoline compounds, which were produced by electrochemical oxidation of the hydroxyimino-phenol derivative 7, followed by Zn[BH 4] 2 reduction. Comparison of the spectroscopic data of the synthetic (±)-1 and (±)-13 resulted in structural revision of the natural calafianin to 13, possessing the trans-relationship between an epoxide and an oxygen of the isoxazoline. In addition, a significant difference of antimicrobial activity between 1 and 13 is discussed.
本文言語 | English |
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ページ(範囲) | 134-139 |
ページ数 | 6 |
ジャーナル | Bulletin of the Chemical Society of Japan |
巻 | 79 |
号 | 1 |
DOI | |
出版ステータス | Published - 2006 11月 7 |
ASJC Scopus subject areas
- 化学 (全般)