Toward bioluminescence in the near-infrared region: Tuning the emission wavelength of firefly luciferin analogues by allyl substitution

Nobuo Kitada, Tsuyoshi Saitoh, Yuma Ikeda, Satoshi Iwano, Rika Obata, Haruki Niwa, Takashi Hirano, Atsushi Miyawaki, Koji Suzuki, Shigeru Nishiyama, Shojiro A. Maki

研究成果: Article査読

10 被引用数 (Scopus)

抄録

The synthesis and bioluminescence of allyl-substituted luciferin derivatives as substrates for firefly luciferase are reported. The allylation of luciferins induced bathochromic shift (15–40 nm) of the bioluminescence emission. Upon combination with other chemical modifications for bioluminescence wavelength tuning, novel red emitting luciferin analogues were obtained with emission maxima at 685 and 690 nm.

本文言語English
ページ(範囲)1087-1090
ページ数4
ジャーナルTetrahedron Letters
59
12
DOI
出版ステータスPublished - 2018 3 21

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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