Toward practical application of paper-based microfluidics for medical diagnostics: state-of-the-art and challenges

Kentaro Yamada, Hiroyuki Shibata, Koji Suzuki, Daniel Citterio

研究成果: Review article

118 引用 (Scopus)

抄録

Microfluidic paper-based analytical devices (μPADs) have emerged as a promising diagnostic platform a decade ago. In contrast to highly active academic developments, their entry into real-life applications is still very limited. This discrepancy is attributed to the gap between research developments and their practical utility, particularly in the aspects of operational simplicity, long-term stability of devices, and associated equipment. On the basis of these backgrounds, this review attempts to: 1) identify the reasons for success of paper-based devices already in the market, 2) describe the current status and remaining issues of μPADs in terms of operational complexity, signal interpretation approaches, and storage stability, and 3) discuss the possibility of mass production based on established manufacturing technologies. Finally, the state-of-the-art in commercialisation of μPADs is discussed, and the “upgrades” required from a laboratory-based prototype to an end user device are demonstrated on a specific example.

元の言語English
ページ(範囲)1206-1249
ページ数44
ジャーナルLab on a Chip - Miniaturisation for Chemistry and Biology
17
発行部数7
DOI
出版物ステータスPublished - 2017

Fingerprint

Microfluidics
Equipment and Supplies
Technology
Research

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Biochemistry
  • Biomedical Engineering

これを引用

@article{221d9f466da545988eafc490a9ef470d,
title = "Toward practical application of paper-based microfluidics for medical diagnostics: state-of-the-art and challenges",
abstract = "Microfluidic paper-based analytical devices (μPADs) have emerged as a promising diagnostic platform a decade ago. In contrast to highly active academic developments, their entry into real-life applications is still very limited. This discrepancy is attributed to the gap between research developments and their practical utility, particularly in the aspects of operational simplicity, long-term stability of devices, and associated equipment. On the basis of these backgrounds, this review attempts to: 1) identify the reasons for success of paper-based devices already in the market, 2) describe the current status and remaining issues of μPADs in terms of operational complexity, signal interpretation approaches, and storage stability, and 3) discuss the possibility of mass production based on established manufacturing technologies. Finally, the state-of-the-art in commercialisation of μPADs is discussed, and the “upgrades” required from a laboratory-based prototype to an end user device are demonstrated on a specific example.",
author = "Kentaro Yamada and Hiroyuki Shibata and Koji Suzuki and Daniel Citterio",
year = "2017",
doi = "10.1039/c6lc01577h",
language = "English",
volume = "17",
pages = "1206--1249",
journal = "Lab on a Chip - Miniaturisation for Chemistry and Biology",
issn = "1473-0197",
publisher = "Royal Society of Chemistry",
number = "7",

}

TY - JOUR

T1 - Toward practical application of paper-based microfluidics for medical diagnostics

T2 - state-of-the-art and challenges

AU - Yamada, Kentaro

AU - Shibata, Hiroyuki

AU - Suzuki, Koji

AU - Citterio, Daniel

PY - 2017

Y1 - 2017

N2 - Microfluidic paper-based analytical devices (μPADs) have emerged as a promising diagnostic platform a decade ago. In contrast to highly active academic developments, their entry into real-life applications is still very limited. This discrepancy is attributed to the gap between research developments and their practical utility, particularly in the aspects of operational simplicity, long-term stability of devices, and associated equipment. On the basis of these backgrounds, this review attempts to: 1) identify the reasons for success of paper-based devices already in the market, 2) describe the current status and remaining issues of μPADs in terms of operational complexity, signal interpretation approaches, and storage stability, and 3) discuss the possibility of mass production based on established manufacturing technologies. Finally, the state-of-the-art in commercialisation of μPADs is discussed, and the “upgrades” required from a laboratory-based prototype to an end user device are demonstrated on a specific example.

AB - Microfluidic paper-based analytical devices (μPADs) have emerged as a promising diagnostic platform a decade ago. In contrast to highly active academic developments, their entry into real-life applications is still very limited. This discrepancy is attributed to the gap between research developments and their practical utility, particularly in the aspects of operational simplicity, long-term stability of devices, and associated equipment. On the basis of these backgrounds, this review attempts to: 1) identify the reasons for success of paper-based devices already in the market, 2) describe the current status and remaining issues of μPADs in terms of operational complexity, signal interpretation approaches, and storage stability, and 3) discuss the possibility of mass production based on established manufacturing technologies. Finally, the state-of-the-art in commercialisation of μPADs is discussed, and the “upgrades” required from a laboratory-based prototype to an end user device are demonstrated on a specific example.

UR - http://www.scopus.com/inward/record.url?scp=85016455940&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85016455940&partnerID=8YFLogxK

U2 - 10.1039/c6lc01577h

DO - 10.1039/c6lc01577h

M3 - Review article

C2 - 28251200

AN - SCOPUS:85016455940

VL - 17

SP - 1206

EP - 1249

JO - Lab on a Chip - Miniaturisation for Chemistry and Biology

JF - Lab on a Chip - Miniaturisation for Chemistry and Biology

SN - 1473-0197

IS - 7

ER -